Contract Research: Pre-clinical Evaluation Service

Pre-clinical evaluation of anti-obesity and anti-diabetic agents – a complete service by experts

Clore Laboratory, Buckingham Institute for Translational Medicine

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Advice on experimental design:

An image showing the effects of obesity on rats

  • On animal models: DIO mice and rats – ob/ob and db/db mice – fa/fa rats and ZDF rats – HFD/STZ mice
  • On output measurements:
  • energy expenditure and RQ
  • thermic response to food
  • basal metabolic rate at thermoneutrality
  • body composition in mice by DEXA or NMR
  • glucose tolerance, insulin tolerance and pyruvate tolerance
  • euglycemic hyperinsulinemic clamps
  • isolated hepatocytes and adipocytes
  • isolated soleus muscle

Services available

Animal and human cells under the microscope

  • animal and human primary cells and cell lines
  • systemic and central Inflammatory markers
  • Oxidative stress markers
  • metabolic parameters such as glucose, lactate, lipids
  • hormones such as insulin, glucagon, GLP-1, and adipokines
  • microarrays, RNA analysis and Western blots
  • hepatic glucose output and tissue glucose uptake
  • liver and muscle toxicology markers
  • images analysis

For confidential enquiries about services available and quotations please contact: 

Clore Laboratory, University of Buckingham, Buckingham MK18 1EG, UK
Dr Mohamed Zaibi
+44 (0)1280 820370